Hydroxychloroquine flunks Phase III trial in mild-to-moderate Covid-19
The study adds to the growing body of evidence that the drug, promoted early in the pandemic by President Trump, is ineffective, despite its getting a briefly renewed lease on life earlier this month thanks to a retrospective analysis.
Results of new clinical trial published late last week have found that hydroxychloroquine – the malaria and autoimmune disease drug that President Donald Trump promoted as a potential “game changer” early in the Covid-19 pandemic – not only failed to improve outcomes in those with mild-to-moderate disease, but also produced a higher rate of cardiac and liver side effects. . . .
The results add to the growing body of evidence not supporting treatment of Covid-19 with hydroxychloroquine, an analogue of chloroquine, which has also been explored without success in Covid-19. Last month, the Food and Drug Administration revoked an emergency use authorization that it had granted to the drug in late March, a move that had been criticized as motivated more by politics than by science.
The drug nevertheless saw a briefly renewed lease on life earlier this month when researchers at the Henry Ford Health System in Detroit published a retrospective analysis of 2,541 hospitalized Covid-19 patients in the International Journal of Infectious Diseases showing that 13% of those treated with the drug died, compared with 26.4% of those who did not receive it. However, while several right-wing media figures celebrated the data, a review in the same journal pointed to numerous confounding factors that called the purported benefit into question. . . .
And two weeks ago, a post-publication peer review in the International Journal of Antimicrobial Agents strongly criticized the original paper that spurred interest in the drug, published earlier this year, pointing to numerous methodological flaws rendering it “nearly if not completely uninformative” and denouncing it as “fully irresponsible.”
Case closed.
Update: Apparently some people are functionally illiterate. Please read the last paragraph above and follow the link.
1 comment:
You mean it's not a game-changer??
It's impossible to effectively restrain a sitting president who is a vulgar, racist sex abuse who spews lies so fast nobody can keep up.
This is why I say it's a really bad idea to elect insane people.
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